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You should not take avanafil if you are allergic to it. Avanafil should not be used together with nitrate medication, such as nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking avanafil with a nitrate medicine for chest pain or heart problems can cause a sudden and serious decrease in blood pressure.

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It is not clear whether avanafil could cause vision loss. Stop using avanafil and get emergency medical help if you have sudden vision loss. FDA pregnancy category C. Avanafil is not for use in women. It is not known whether avanafil will harm an unborn baby. Although avanafil is not for use in women, it is not known if this medication passes into breast milk or if it could harm a nursing baby.

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